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IgA Nephropathy: A Twenty Year Retrospective Single Center Experience

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Author(s): Jacob Rube | Freya Tarapore | Rachel Frank RN CNN | Alexandra Peyser | Bari Scheckner | Suzanne Vento RN | Cathy Hoffman RN | Douglas Charney | Elsa Valderamma | Beatrice Goilav | Howard Trachtman

Journal: Clinical Medicine : Pediatrics
ISSN 1178-220X

Volume: 3;
Start page: 19;
Date: 2009;
Original page

Keywords: IgA nephropathy | severity | retrospective | kidney biopsy

ABSTRACT
IgA nephropathy (IgAN) is a common glomerular disease whose etiology is unknown. Previous studies have described the clinical and laboratory features but none have specifically compared patients during different time periods. This 20 year retrospective study was performed to assess trends in the severity of IgAN from 1989–2008. We reviewed 57 patient charts that contained a confirmed biopsy diagnosis of IgAN and recorded data at the time of diagnosis and the final follow-up appointment. Clinical data included physical examination, urine, and blood tests. Patients were separated into two cohorts, Cohort 1 1989–1998 and Cohort 2 1999–2008. An increase in severity was noted in Cohort 2 based on a significantly higher Up/c and lower serum albumin level. Other prognostic indicators including GFRe, hematocrit, and glomerular injury score also demonstrated a trend towards more severe disease over the past 20 years. The patients in both Cohorts received similar treatments and had comparable renal function at the last follow-up visit. Based on our findings, we suggest that although a kidney biopsy is required to diagnose IgAN, the procedure may not be necessary in patients clinically suspected of having the disease but who have normal kidney function and minimal urine abnormalities.
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