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IgG Avidity Test for the Diagnosis of Acute Toxoplasma gondii Infection in Early Pregnancy

Author(s): Shabnam Pour Abolghasem | Mohammad Reza Bonyadi | Zohre Babaloo | Abolfazl Porhasan | Behroz Nagili | Omid Ali Gardashkhani | Parviz Salehi | Mohammad Hashemi | Mojtaba Varshoghi | Gafar Olade Gaffari

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 4;
Start page: 251;
Date: 2011;
Original page

Keywords: Acute Toxoplasmosis | Avidity | IgG | IgM | Pregnancy

Background: Toxoplasmosis is well known as an important infection in pregnantwomen. Although many serologic methods are available, diagnosis of early Toxoplasmosismay be extremely difficult. Objective: To detect the Toxoplasma IgG antibodiesdeveloped at the early stage of infection in pregnant women. Methods: 225 pregnantwomen, who were in the 2nd to 4th month of their pregnancy, enrolled in this study.Anti-toxoplasma IgG, IgM and IgG avidity were evaluated by ELISA method. Results:The patients were categorized into three groups as follows: Group A, 124 cases; IgG+,IgM+, 55.1%; group B, 99 cases; IgG+, IgM-, 44%; and group C, 2 cases; IgG -, IgM +,0.9%. Fifty five percent of the pregnant women had positive IgG and IgM among which7.1% had low avidity which revealed an active infection in the pregnant women. In thecurrent study, 44% of pregnant women had positive IgG and negative IgM, all of whichhad high avidity, which is an indication that in our population the level of toxoplasmosisinfection is high and most women have had contacts with this parasite before pregnancy.Conclusion: In this study, the low avidity test was 7.1% showing that the occurrenceof toxoplasmosis infection is still a serious issue. Observation of 45.8% high avidityamong group A suggests that either IgM has a high half-life or there is a false positiveIgM as a result of rheumatologic disorders. Therefore, avidity test is important inpredicting maternal toxoplasmosis which is of value in disease treatment.
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