Academic Journals Database
Disseminating quality controlled scientific knowledge

IL-10-IFN-γ Double Producers CD4+ T Cells Are Induced by Immunization with an Amastigote Stage Specific Derived Recombinant Protein of Trypanosoma Cruzi

ADD TO MY LIST
 
Author(s): Yevel Flores-García, José Luis Rosales-Encina, Abhay R. Satoskar, Patricia Talamás-Rohana

Journal: International Journal of Biological Sciences
ISSN 1449-2288

Volume: 7;
Issue: 8;
Start page: 1093;
Date: 2011;
Original page

ABSTRACT
During the acute phase of infection, T. cruzi replicates extensively and releases immunomodulatory molecules that delay parasite-specific responses mediated by effector T cells. This mechanism of evasion allows the parasite to spread in the host. Parasite molecules that regulate the host immune response during Chagas'disease have not been fully identified. GPI-anchored mucins, glycoinositolphospholipids, and glycoproteins comprise some of the most abundant T. cruzi surface molecules. IL-10 IFN-γ-secreting CD4+ T cells are activated during chronic infections and are responsible for prolonged persistence of parasite and for host protection against severe inflammatory responses. In this work we evaluated the role of rMBP::SSP4 protein of T. cruzi, a recombinant protein derived from a GPI anchored antigen, SSP4, as an immunomodulator molecule, finding that it was able to induce high concentrations of IL-10 and IFN-γ both in vivo and in vitro; during this last condition, both cytokines were produced by IL-10-IFN-γ-secreting CD4+ T cells.
Save time & money - Smart Internet Solutions     

Tango Rapperswil
Tango Rapperswil