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Immunoekspresja białek związanych z apoptozą i proliferacją w surowiczych nowotworach jajnika

Author(s): Paweł Stawerski | Małgorzata Wągrowska-Danilewicz | Olga Stasikowska | Marian Danilewicz

Journal: Przegląd Menopauzalny
ISSN 1643-8876

Volume: 14;
Issue: 1;
Start page: 23;
Date: 2010;
Original page

Keywords: apoptosis | proliferation | serous ovarian tumours | CAS | Ki-67

Introduction: Ovarian cancer takes fourth place as a cause of death from all cancers and first place fromgynaecological malignancies in Poland. Recent investigations have noted the prognostic significance of proteinslinked with proliferation (Ki-67) and apoptosis (CAS – cellular apoptosis susceptibility protein).The aim of the study was to evaluate the immunoexpression of CAS and Ki-67 proteins in metastatic andnon-metastatic serous ovarian tumours, as well as to find possible relationships between this immunoexpressionand tumour proliferation activity. Material and methods: The analysis comprised 43 women diagnosed and treated for malignant epithelialovarian tumours. The immunoexpression of CAS protein was assessed semiquantitatively, whereas immunoexpressionof Ki-67 was performed using a computer image analysis system. Results: The immunoexpression of both CAS and Ki-67 proteins was significantly increased in the metastaticgroup as compared with patients without metastases. Also, a positive correlation was found between immunoexpressionof Ki-67 and CAS protein, but this correlation was not significant. Conclusions: In conclusion, our data suggest that increased immunoexpression of CAS and Ki-67 proteins inserous ovarian tumours may be helpful in identifying cases of higher metastatic potential.
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