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Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases

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Author(s): Paulo RC Almeida | Francisco VA Ferreira | Cássio C Santos | Francisco D Rocha-Filho | Raul RP Feitosa | Esther AA Falcão | Belise K Cavada | Roberto CP Lima-Júnior | Ronaldo A Ribeiro

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 18;
Issue: 8;
Start page: 778;
Date: 2012;
Original page

Keywords: Cyclooxygenase-2 | Gastric carcinoma | Immunoexpression | Lymph node metastases | Tissue microarray

ABSTRACT
AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically significant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs freq- uently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.
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