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Immunoglobulin genes and diversity: what we have learned from domestic animals

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Author(s): Sun Yi | Liu Zhancai | Ren Liming | Wei Zhiguo | Wang Ping | Li Ning | Zhao Yaofeng

Journal: Journal of Animal Science and Biotechnology
ISSN 1674-9782

Volume: 3;
Issue: 1;
Start page: 18;
Date: 2012;
Original page

Keywords: Diversity | Domestic animals | Immunoglobulin gene

ABSTRACT
Abstract This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α. Two poultry species (chickens and ducks) express three IgH isotypes, μ, υ, and α, but not δ. The κ and λ light chains are both utilized in the four livestock species, but only the λ chain is expressed in poultry. V(D)J recombination, somatic hypermutation (SHM), and gene conversion (GC) are three distinct mechanisms by which immunoglobulin variable region diversity is generated. Different domestic animals may use distinct means to diversify rearranged variable regions of Ig genes.
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