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 Immunohistochemical Expression of ki-67 and p53 in Colorectal Adenomas: A Clinicopathological Study

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Author(s): Faris Lutfi Nussrat | Hussam Hasson Ali | Haider Ghazi Hussein | Raghad Jawad Al-Ukashi

Journal: Oman Medical Journal
ISSN 1999-768X

Volume: 26;
Issue: 856401;
Start page: 229;
Date: 2011;
Original page

Keywords: Colorectal adenomas. | Dysplasian | p53o | ki-67 expressioni | Immunohistochemical express

ABSTRACT
 Objectives: To evaluate the significance of P53 and Ki-67 expression as immunohistochemical markers in early detection of premalignant changes in different types of colorectal adenomas. Also, to correlate immunohistochemical expression of the two markers with different clinicopathological parameters including; age, and sex of the patient, type, site, size and grade of dysplasia of colorectal adenomas.Methods: Forty-seven polypectomy specimens of colorectal adenomas were retrieved from the archival materials of the Gastrointestinal and Hepatic Diseases Teaching Hospital in Baghdad from 2009 - 2010. Four µm section specimens were stained by immunohistochemical technique with Ki-67 and P53 tumor markers. P-values
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