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Immunohistochemical expression of protein p16 in Wilms' tumor

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Author(s): Basta-Jovanović Gordana | Suzić Slavica | Savin Marina | Petronijević Nataša | Radonjić Nevena | Đuričić S. | Jovanović Milena | Radojević-Škodrić Sanja

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 58;
Issue: 4;
Start page: 297;
Date: 2008;
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Keywords: cell cycle | protein p16 | immunohistochemical | swine | Wilms tumor

ABSTRACT
Proliferative disorders including tumors are recognized as diseases of the cell cycle in which the crucial role belongs to the cyclindependent kinase family. The aim of this study was to investigate the expression of protein p16 in the normal kidney, and in Wilms tumor by immunohistochemistry to correlate the obtained results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/II, showing no statistically significant correlation (p>0.05). Intermediate risk groups of Wilms tumor showed more frequent p16 expression in comparison with high risk cases, showing no statistical significance (p>0.05). Protein p16 expression was detected in all histologic types of Wilms tumor with the highest expression in the predominantly blastemal type (50%). There was a statistically significant difference between p16 expression in this and its expression in other histological types (p
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