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Immunohistochemical Expression of Vascular Endothelial Growth Factor and Its Correlation with Tumor Grade in Breast Ductal Carcinoma

Author(s): Maryam Ghasemi | Omid Emadian | Farshad Naghshvar | Ahmadreza Bekhradnia | Saeid Abediankenari | Laleh Vahedi Larijani | Roghaieh Moghimpour

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 49;
Issue: 12;
Start page: 776;
Date: 2011;
Original page

Keywords: VEGF | Breast neoplasms | Angiogenesis

"nBreast cancer is the most common cause of cancer-related death in female, after lung cancer. Angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. The role of vascular endothelial growth factor that assumed to be most potent angiogenesis factor is ambiguous in breast cancer. This study described the correlation between vascular endothelial growth factor expression and tumor grade, to define the breast cancer patients who responder to anti-vascular endothelial growth factor therapy. In this research, 200 cases of histological proved invasive ductal breast carcinomas analyzed for vascular endothelial growth factor expression by immunohistochemical staining via cross-sectional descriptive study. Vascular endothelial growth factor expressed in 72.54% of the breast cancers. The VEGF was more detectable in grade I (78.5%) than grade II (77.4%) and grade III (56.2%). There is a significant correlation between tumor grade and VEGF expression (P
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