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Immunological Changes in Mesothelioma Patients and Their Experimental Detection

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Author(s): Megumi Maeda | Yoshie Miura | Yasumitsu Nishimura | Shuko Murakami | Hiroaki Hayashi | Naoko Kumagai | Tamayo Hatayama | Minako Katoh | Naomi Miyahara | Shoko Yamamoto | Kazuya Fukuoka | Takumi Kishimoto | Takashi Nakano | Takemi Otsuki

Journal: Clinical Medicine : Circulatory, Respiratory and Pulmonary Medicine
ISSN 1178-1157

Volume: 2;
Start page: 11;
Date: 2008;
Original page

Keywords: Keywords: asbestos | immunology | mesothelioma | chrysotile

ABSTRACT
It is common knowledge that asbestos exposure causes asbestos-related diseases such as asbestosis, lung cancer and malignant mesothelioma (MM) not only in people who have handled asbestos in the work environment, but also in residents living near factories that handle asbestos. These facts have been an enormous medical and social problem in Japan since the summer of 2005. We focused on the immunological effects of asbestos and silica on the human immune system. In this brief review, we present immunological changes in patients with MM and outline their experimental detection. For example, there is over-expression of bcl-2 in CD4+ peripheral T-cells, high plasma concentrations of interleukin (IL)-10 and transforming growth factor (TGF)-ß, and multiple over-representation of T cell receptor (TcR)-Vß in peripheral CD3+ T-cells found in MM patients. We also detail an experimental long-term exposure T-cell model. Analysis of the immunological effects of asbestos may help our understanding of the biological effects of asbestos.
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