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Immunomodulatory Activity of the Aque-ous Extract of Seeds of Abrus precatorius Linn (Jequirity) in Mice

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Author(s): Anita Tilwari | Narmada Prasad Shukla | Uma Devi Pathirissery

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 2;
Start page: 96;
Date: 2011;
Original page

Keywords: Abrus precatorius | Delayed Type Hypersensitivity | Haemagglutination | Immunomodulation | Phagocytic Index

ABSTRACT
Background: Various compounds of plant origin have been widely investigated since ancient times for their possible immunomodulatory properties as well as for the treat-ment of a wide range of diseases. Objective: To study the immunomodulatory functions of the aqueous extract of the seeds of Abrus precatorius commonly known as Indian liquorice (Fabaceae), a medicinal plant native to central India. Methods: Swiss albino mice were intraperitoneally treated with three doses (0.75, 1.25 and 2.5 µg/kg b.w.) of extract for 7 days. Relative organ weight, delayed type hypersensitivity (DTH) re-sponse, haemagglutination titre (HT) and Phagocytic index (PI) were studied in various groups of animals. Results: The results showed no significant difference in relative or-gan weight of spleen, liver, thymus and kidney in various groups of animals. Treatment of rats with increasing concentrations of the extract decreased the footpad thickness in-dicating a dose related inhibitory effect of the extract on delayed type hypersensitivity. In the HT test, the plant extract showed a suppressive effect at all doses, and these changes were significant as the dose increased. Phagocytic index was also increased in a dose dependent manner. Conclusion: The reduction of antibody titre, delayed type hy-persensitivity response and the increase in phagocytic index indicates that Abrus preca-torius has an inhibitory effect on the immune functions in mice.

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