Academic Journals Database
Disseminating quality controlled scientific knowledge

Immunopathology of Chagas disease

ADD TO MY LIST
 
Author(s): Andrade Zilton A

Journal: Memórias do Instituto Oswaldo Cruz
ISSN 0074-0276

Volume: 94;
Issue: suppl.1;
Start page: 71;
Date: 1999;
Original page

Keywords: Trypanosoma cruzi | immunopathology | myocarditis

ABSTRACT
The main clinical forms of Chagas disease (acute, indeterminate and chronic cardiac) present strong evidences for the participation of the immune system on pathogenesis. Although parasite multiplication is evident during acute infection, the intense acute myocarditis of this phase exhibits clear ultrastructural signs of cell-mediated immune damage, inflicted to parasitized and non-parasitized myocardiocytes and to the endothelium of myocardial capillaries (microangiopathy). Inflammation subsides almost completely when immunity decreases parasite load and suppressor factors modulate host reaction, but inflammation does not disappear when the disease enters the indeterminate phase. Inflammation becomes mild and focal and undergoes cyclic changes leading to complete resolution. However, the process is maintained because the disappearance of old focal lesions is balanced by the upsurge of new ones. This equilibrium allows for prolonged host survival in the absence of symptoms or signs of disease. The chronic cardiac form is represented by a delayed-type, cell-mediated diffuse myocarditis, that probably ensues when the suppressive mechanisms, operative during the indeterminate phase, become defaulted. The mechanism responsible for the transition from the indeterminate to the cardiac form, is poorly understood.
Why do you need a reservation system?      Affiliate Program