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Impact of body mass index on correlation between insulin resistance and progesterone 17 oh concentrations in women with polycystic ovarian syndrome

Author(s): Soheila. Arefi | Sayeh. Motaghi | Ali. M. Sharifi

Journal: International Journal of Collaborative Research on Internal Medicine & Public Health
ISSN 1840-4529

Volume: 3;
Issue: 3;
Start page: 235;
Date: 2011;
Original page

Keywords: Polycystic ovary syndrome | insulin resistance | progesterone 17 oh

Polycystic ovary syndrome (PCOS) is one of the most common endocrine –metabolic disorders affectingabout 7% of reproductive- age women. The symptoms and severity of the syndrome vary greatly amongwomen. While the causes are unknown insulin resistance, diabetes and obesity are all strongly correlatedwith PCOS. While most women with PCOS frequently have higher levels of progesterone 17 oh, so farfew studies have evaluated the correlation between insulin resistance and progesterone 17 oh in womenwith PCOS in regard to BMI.A total of thirty one women with PCOS diagnosed by Rotterdam criteria andthirty six control subjects without PCOS were enrolled in this cross sectional study. The serum sampleswere collected for determination of fasting insulin level, insulin resistance (IR), fasting blood sugar (FBS)and progesterone 17 oh. Both case and control group were subdivided into three groups (normal,overweight, obese) according to their BMI and were evaluated regarding to their fasting insulin level, IR,FBS and progesterone 17 oh. The present study showed that fasting insulin was higher in case group(p=0.004), and there was a significant enhancement in insulin resistance (p=0.02) in case group. Aftersubdividing the subjects regarding their BMI a significant increase could be observed in insulin resistancein normal case group (p= 0.02), and fasting insulin (P=0.004) was also found to be significantly higher innormal weight PCOS patients than the normal weight control group. Progestrone17 oh levels was notsignificantly different in case group (neither before nor after subdivision). A positive correlation (r=0.84;p = 0.02) between insulin resistance and progesterone 17oh concentrations in overweight women withPCOS was demonstrated. There was also a positive correlation (r=0.87; p=0.002) between progesterone17 oh concentrations and fasting insulin levels in overweight women with PCOS. The current resultssuggested that the probable insulin resistance/ hyperinsulinemia responsibility for high progesterone 17oh concentrations may be partially due to elevated body mass index as such a correlation between IR andprogesterone 17 oh concentrations could not be seen in normal case group.
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