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Impact of interleukin-27 on replication of hepatitis C virus

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Author(s): Scotto G | Giammario A | Campanale F | D’Addiego G | Fazio V

Journal: International Journal of Interferon, Cytokine and Mediator Research
ISSN 1179-139X

Volume: 2011;
Issue: default;
Start page: 79;
Date: 2011;
Original page

ABSTRACT
Gaetano Scotto1, Adele Giammario1, Francesca Campanale1, Giovanna D’Addiego1, Vincenzina Fazio21Clinic of Infectious Diseases, University of Foggia, Italy; 2Clinical Chemistry Laboratory, Hospital of Foggia, ItalyAbstract: Recently, different interleukins have been associated with responses to PEGylated interferon and ribavirin and spontaneous clearance of acute hepatitis C virus (HCV) infection (interleukin [IL]-28B) or with the development of a novel immunotherapeutic strategy for HCV infection (IL-27). IL-27 is a helical cytokine belonging to the IL-6/IL-12 cytokine family with a broad range of anti-inflammatory properties. Some studies demonstrated that IL-27 stimulates hepatoma cells and hepatocytes by inducing a sustained signal transducer and activator of transcription (STAT1 and STAT3) activation. Moreover, IL-27 induces interferon-α-like responses including the induction of antiviral genes (ribonucleic acid-dependent protein kinase), oligoadenylate synthetase, and myxovirus protein. In this review we examine the research on IL-27 and its potential role in therapy for HCV, including the capability to inhibit replication of HCV.Keywords: interleukin-27, hepatitis C virus, chronic liver disease, chronic hepatitis C infection
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