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Impact of Mitoxantrone on MRI Findings in Patients with Secondary Progressive Multiple Sclerosis

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Author(s): Saeed Naghibi | Amirhossein Hashemi | Maryam Afraze

Journal: Iranian Journal of Radiology
ISSN 1735-1065

Volume: 7;
Issue: S1;
Start page: 2;
Date: 2010;
Original page

Keywords: keyword

ABSTRACT
Objective: Determining the effect of Mitoxantrone on MRI findings in patients with secondary progressive multiple sclerosis (SPMS) "nPatients and Methods: In clinical trial, 25 SPMS patients were enrolled in this study. Brain and spinal cord MRI were performed before and after treatment with Mitoxantrone. The number, shape, and distribution of the plaques and the size of the largest and smallest plaques were assessed in T1 W, T2 W and FLAIR sequences and compared before and after treatment. "nResults: The mean age of the patients was 38.9 years (24-57). There were 15 women and 10 men. The mean plaque count reduction after treatment was 3±2.6, 3.3±2.5 and 3.1±2.3 in T1W, T2W and FLAIR sequences, respectively (all p
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