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Impact of Scattered Radiation onTestosterone Deficiency and MaleHypogonadism in Rectal Cancer Treatedwith External Beam Pelvic Irradiation

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Author(s): Niloofar Ahmadloo | Farzad Bidouei | Mohammad Amin Mosleh-Shirazi | Gholam Hossein Omrani | Shapour Omidvari | Ahmad Mosalaei | Mansour Ansari | Halimeh Khatoon Ahmadi | Mohammad Mohammadianpanah

Journal: Middle East Journal of Cancer
ISSN 2008-6709

Volume: 1;
Issue: 3;
Start page: 115;
Date: 2010;
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Keywords: Rectal carcinoma | Male sex hormones | Pelvic irradiation | LH | FSH | Testosterone

ABSTRACT
Background: We performed a prospective study to evaluate the effects of pelvic irradiation on FSH, LH and testosterone levels in male patients with rectal adenocarcinoma. Our aim was to compare the level of male sex hormones in peripheral blood serum before and after pelvic irradiation.Methods:The eligible participants were 40 men with rectal adenocarcinoma who underwent pelvic radiotherapy as part of their treatment for primary tumor, either beforeor after surgery. All patients received a 50-Gy radiation dose to the pelvis, 2 Gy perfraction, five days per week. Blood was sampled three times during the study: once before radiation, at the end of the radiation course and 4 to 6 weeks after radiotherapy.Results:Median age of the patients was 58 years (range 18-82). The mean testis dose of radiation per fraction in all 40 patients was 16.3 cGy with a standard deviation of 15.22 (range 5.5-64.8). Serum levels of FSH revealed a significant increase from 7.5 ± 1.7 IU/L(before treatment) to 20.9 ± 17.8 IU/L[end of radiotherapy (P
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