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Impaired Iron Status in Aging Research

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Author(s): Jinze Xu | Zhenhua Jia | Mitchell D. Knutson | Christiaan Leeuwenburgh

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 13;
Issue: 2;
Start page: 2368;
Date: 2012;
Original page

Keywords: labile iron | iron accumulation | oxidative damage | mitochondrial dysfunction | aging

ABSTRACT
Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
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