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Implications for the mammalian sialidases in the physiopathology of skeletal muscle

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Author(s): Fanzani Alessandro | Zanola Alessandra | Faggi Fiorella | Papini Nadia | Venerando Bruno | Tettamanti Guido | Sampaolesi Maurilio | Monti Eugenio

Journal: Skeletal Muscle
ISSN 2044-5040

Volume: 2;
Issue: 1;
Start page: 23;
Date: 2012;
Original page

Keywords: Sialidases | Gangliosides | Glycoproteins | Myogenesis | Skeletal muscle

ABSTRACT
Abstract The family of mammalian sialidases is composed of four distinct versatile enzymes that remove negatively charged terminal sialic acid residues from gangliosides and glycoproteins in different subcellular areas and organelles, including lysosomes, cytosol, plasma membrane and mitochondria. In this review we summarize the growing body of data describing the important role of sialidases in skeletal muscle, a complex apparatus involved in numerous key functions and whose functional integrity can be affected by various conditions, such as aging, chronic diseases, cancer and neuromuscular disorders. In addition to supporting the proper catabolism of glycoconjugates, sialidases can affect different signaling pathways by desialylation of many receptors and modulation of ganglioside content in cell membranes, thus actively participating in myoblast proliferation, differentiation and hypertrophy, insulin responsiveness and skeletal muscle architecture.
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