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An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole- 1-Carbaldehyde Derivatives

Author(s): S. B. Zangade | A. T. Shinde | A. Y. Vibhute | Y. B. Vibhute

Journal: Pakistan Journal of Chemistry
ISSN 2220-2625

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2012;
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Keywords: Synthesis

An improved condensation of substituted chalcones 1a-g with hydrazine hydrate and formic acid in 2-methoxyethanol to afford new series of 4,5-dihydro-pyrazole-1-carbaldehyde derivatives 2a-g. Clean reaction conditions, simple workup procedure and short reaction time giving high yields of product are notable advantages of method. All newly synthesized compounds characterized by chemical test, spectral and elemental analysis. Further, all newly synthesized compounds were screened for their antimicrobial activity. Most of these title compounds exhibited potent activity.
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