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Improvement of Urodynamic Indices by Single Dose Oral Tadalafil in Men With Supra Sacral Spinal Cord Injury

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Author(s): Karim Taie | Dinyar Khazaeli | Hayat Moombeini | Mohammad Salari Panah firouzabadi

Journal: Urology Journal
ISSN 1735-1308

Volume: 7;
Issue: 4;
Start page: 249;
Date: 2010;
Original page

Keywords: urodynamic | spinal cord injury | phosphodiesterase inhibitors | drug therapy

ABSTRACT
PURPOSE: To investigate the changes in urodynamic indices following a single dose of oral tadalafil in patients with supra sacral spinal cord injury (SCI). MATERIALS AND METHODS: Urodynamic study was accomplished on 20 patients with supra sacral SCI before and one hour after administration of 20 mg oral tadalafil as a single dose. Changes in the bladder capacity and compliance, maximum voiding detrusor pressure, and maximum detrusor filling pressure before and after tadalafil administration were recorded. RESULTS: Following administration of 20 mg oral tadalafil, there was a significant increase in the bladder compliance (from 12.7 to 18.5 mL/cmH20, P < .001), bladder capacity (from 169.8 to 198.5 mL, P < .001), maximum voiding detrusor pressure (from 64.8 to 48.6 cmH2O, P < .001), and maximum detrusor filling pressure (from 24.3 to 14.0 cmH2O, P < .001). CONCLUSION: Single dose of oral tadalafil has significant positive effects onurodynamic indices in patients with supra sacral SCI.
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