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In-vitro Dissolution Rate Enhancement of Indomethacin with PEG 4000, Sodium benzoate, Niacinamide by solid Dispersion technique.

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Author(s): Jitendra Jain*a, Mital Patani b, Khemchand Mathuriaa, Vikas guptaa , Navneet Upadhyay a

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3386;
Date: 2011;
Original page

Keywords: Indomethacin | PEG 4000 | Sodium benzoate | Niacinamide | Fourier Transformation-Infrared Spectroscopy

ABSTRACT
The present investigation was to improve the solubility and dissolution rate of a poorly water soluble drug Indomethacin by using solid dispersion technique. Toenhance the dissolution rate formulate solid dispersions using different solubilizers such as polyethylene glycol 4000, Sodium benzoate, Niacinamide using solventevaporation method. The Solid dispersion of indomethacin with PEG 4000, Sodium benzoate, Niacinamide were prepared at 1:6, 1:8, 1:10 and 1:12 ratio by solventevaporation method. The interaction of Indomethacin with different solubilizers was studied by Fourier Transformation-Infrared (FTIR) Spectroscopy and X-raydiffraction (XRD) studies. Solid dispersions were characterized for physicochemical properties like drug content, surface morphology and dissolution studies. Thedissolution of the pure drug and prepared solid dispersion showed 67.23 + 3.8 % to 92.30 + 5.2 % release respectively within 30 min., On the basis of these resultsit was observed that there is increase in peak plasma concentration compared to pure drug. Solid dispersion is an effective technique in increasing solubility anddissolution rate of the poorly soluble drugs.
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