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IN-VITRO AND IN-VIVO ANTIASTHMATIC STUDIES OF CLERODENDRUM SERRATUM LINN IN GUINEA PIGS

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Author(s): Santosh S. Bhujbal

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 4;
Start page: 2;
Date: 2010;
Original page

Keywords: bharangi | antiasthamatic activity | histamine induced bronchoconstrictio

ABSTRACT
Clerodendrum serratum Linn ( Verbenaceae) known as ‘Bharangi’ in Ayurveda and ‘Siriutekku” in Siddha system of medicine is claimed to be useful in pain, inflammation, rheumatism, respiratory disorders, fever and malarial fever .Ethanolic extract of roots of Clerodendrum serratum. was evaluated for antiasthmatic activity by employing in-vivo and in-vitro screening models in guinea pigs. Preliminary phytochemical screening revealed presence of Flavonoids,Saponins and Sterols. The results of the present study confirmed that the ethanolic extract of the roots of the plant produced significant dose-dependent antiasthamatic activity at 50,100 and 200mg/kg p.o

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