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IN-VITRO STUDIES OF ANTIBACTERIAL AND CYTOTOXIC PROPERTIES OF FLACOURTIA JANGOMAS

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Author(s): Salman Bin Hosain

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 2;
Issue: 11;
Start page: 2786;
Date: 2011;
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Keywords: Antibacterial | Cytotoxicity | Minimum inhibitory concentration (MIC) | Brine Shrimp lethality bioassay | Flacourtia jangomas

ABSTRACT
The Plant Flacourtia jangomas have shown considerable antibacterial and cytotoxicity properties. The extracts were found to have different levels of cytotoxicity properties in different concentration. The crude extract of the plant Flacourtia jangomas was subjected to in vitro microbiological screening for studying anti-microbial activity of the extract against a wide of Gram-positive and Gram- negative bacteria by disc diffusion method. The result so obtained was compared with that of a standard antibiotic, Amoxicillin. The extract shows good activity against Shigella shiga and Bacillus megaterium and moderate activity against Bacillus cerus and poor activity against E. coli. The Minimum Inhibitory Concentration (MIC) values of the plant extract investigated was 31.25 mg/ml and 125 mg/ml for Bacillus megaterium and E. coli respectively. For Cytotoxicity, brine shrimp lethality bioassay was used. We used Vincristine sulfate as a standard reference. The LC50 value of standard was 12.58 mg/ml.
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