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INCIDENCE OF ACUTE MYELOID LEUKEMIA AFTER BREAST CANCER

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Author(s): Caterina Giovanna Valentini | Luana Fianchi | Maria Teresa Voso | Morena Caira | Giuseppe Leone | Livio Pagano

Journal: Mediterranean Journal of Hematology and Infectious Diseases
ISSN 2035-3006

Volume: 3;
Issue: 1;
Start page: e2011069;
Date: 2011;
Original page

Keywords: Leukemia | breast cancer | therapy related neoplasm | secondary leukemias

ABSTRACT
Breast cancer is the most frequent cancer among women and the leading cause of death among middle-aged women. Early detection by mammography screening and improvement of therapeutic options have increased breast cancer survival rates, with the consequence that late side effects of cancer treatment become increasingly important. In particular, patients treated with adjuvant chemotherapy regimens, commonly including alkylating agents and anthracyclines, are at increased risk of developing leukemia, further enhanced by the use of radiotherapy. In the last few years also the use of growth factors seems to increase the risk of secondary leukemia. The purpose of this review is to update epidemiology of therapy-related myeloid neoplasms occurring in breast cancer patients
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