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INCORPORATION OF OMEGA-3 FATTY ACID AND SYNTHESIS OF THEIR METABOLITES IN MUSCLE TISSUE IN MICE FED WITH FLAXSEED AND PERILLA-ENRICHED DIET

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Author(s): Sheisa Cyleia Sargi | Flavia Braidotti Stevanato | Marcia Machado de Oliveira Dalalio | Damila Rodrigues de Morais | Amarilis Giaretta de Moraes | Jeane Eliete Laguila Visentainer | Jesui Vergilio Visentainer

Journal: American Journal of Applied Sciences
ISSN 1546-9239

Volume: 10;
Issue: 4;
Start page: 367;
Date: 2013;
Original page

Keywords: Incorporation | Omega-3 | Omega-6 | Supplementation | Mice

ABSTRACT
Polyunsaturated fatty acids omega 3 and omega 6 are believed to have beneficial physiological effects on the human body. The present study aimed to evaluate the incorporation and synthesis of omega-3 fatty acid and their metabolites in muscle tissue in mice fed with a flaxseed and perilla-enriched diet. The animals were fed a diet supplemented with flaxseed and perilla meals for fifty-six days and control animals received a commercial diet. Mice were sacrificed on the 7th, 28th and 56th days and the muscle tissue was collected. The FA concentration was analyzed by gas chromatography. The levels of alpha-Linolenic Acid (LNA) and their metabolites, Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) increased as a function of feeding length in the groups given the supplemented diet. LNA was incorporated into muscle tissue and conversion into Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFA) was observed. The muscle tissue of animals fed with enriched diets presented a high sum of n-3 FA and high concentrations of LNA, EPA and DHA, as compared to mice fed commercial diet. The intake of flaxseed and perilla-meal enriched diets by mice may result in the deposition of LNA and its metabolites EPA and DHA into muscle tissue.

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