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Increase of bcl-2 Protein Expression in Aggressive Basal Cell Carcinoma of Head and Neck

Author(s): Cláudia CAZAL | Mariana Roesch ELY | Ana Paula Veras SOBRAL | Wilton Wilney Nascimento PADILHA

Journal: Pesquisa Brasileira em Odontopediatria e Clínica Integrada
ISSN 1519-0501

Volume: 6;
Issue: 3;
Start page: 267;
Date: 2006;
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Keywords: Basal cell carcinoma | Skin cancer | Bcl-2 genes

Objective: The aim of this study was to verify the bcl-2 protein expression in 22 cutaneous basal cell carcinomas (BCC) of the head and neck, and to compare it with its aggressive behavior. Method: Tumors were histologically classified in non-aggressive (BCC 1) and aggressive (BCC 2) and then submitted to the immunohistochemistry technique with the streptavidin-biotin peroxidase method using the anti-bcl-2 antibody. Results: After proceeding to morphological analysis, sixteen tumors (72.7%) were considered aggressive and six (27.3%) non-aggressive. Immunohistochemistry analysis showed that thirteen (59.1%) lesions were positive staining and nine (40.9%) were negative to the bcl-2 protein. Considering the positive lesions, 12 (92.3%) were aggressive and one (7.7%) non-aggressive. The relation between bcl-2 protein staining and the tumor aggressiveness was statistically significant (p
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