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Increased Cerebral Cortex Perfusion in Stroke Patients with Cognitive Disorder Following Cilostazol Administration, Two Cases Report

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Author(s): Yukihiro Hara | Shigeru Obayashi

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 03;
Issue: 04;
Start page: 357;
Date: 2012;
Original page

Keywords: Stroke | Cognitive Disorder | Brain Perfusion | Antiplatelet Drug | NIRS

ABSTRACT
Objective: In our search for a new augmentation therapy for stroke patients, we administered cilostazol, an antiplatelet agent. Subjects: The patients suffered from mild hemiparesis or cognitive disorder showing reduced cerebral perfusion in the prefrontal cortex. Methods: We evaluated the functional cerebral blood flow (CBF) before and after the administration of cilostazol using near-infrared resonance spectroscopy (NIRS) during a verbal fluency task (VFT). Results: For the patient with cognitive disorder, statistically significant improvements were observed in the number of generated words in the VFT before and after administration of 50 mg cilostazol (p

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