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Induction of apoptosis by the aqueous and ethanolic leaf extract of Vitex negundo L. in MCF-7 human breast cancer cells

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Author(s): Arulvasu C. | Prabhu D. | Manikandan R. | Srinivasan P. | Dinesh D. | Babu G. | Sellamuthu S.

Journal: International Journal of Drug Discovery
ISSN 0975-4423

Volume: 2;
Issue: 1;
Start page: 01;
Date: 2010;
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Keywords: Anti-cancer | anti-proliferative | breast cancer | cytotoxicity | V. negundo | MCF-7

ABSTRACT
The aim of this investigation was to evaluate the anti-proliferative potential of aqueous andethanolic extract from Vitex negundo against human breast cancer cell (MCF-7). The aqueous and ethanolextract from V. negundo potently inhibited growth of MCF-7 in a concentration-dependent manner. V.negundo pretreatment resulted in deferential cell viability and IC50 value were observed in MCF-7 cell linebut not in control cell line. The above result suggested that V. negundo has a potential benefits in breastcancer cells.

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