Academic Journals Database
Disseminating quality controlled scientific knowledge

The induction of inflammation in mouse tails with Aspergillus oryzae protease and the inhibitory effects of synthetic and natural sub stances in vitro

ADD TO MY LIST
 
Author(s): Šutiak V. | Korenek M. | Sutiakova Irena | Korenekova Beata | Sobekova Anna | Vaško L. | Neuschl J.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 52;
Issue: 5-6;
Start page: 345;
Date: 2002;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: inflammation | inhibitors | measurements | mice | oedema | protease

ABSTRACT
Four groups of male mice were injected with doses from 0.005 to 1.0 mg of protease ex Aspergillus oryzae (PAO) in 20.0 (l of a 0.9 % physiological saline solution (PSS) per mouse s.c. into their tails. The control mice received 20.0 (l of 0.9% PSS only. The inflammation of the tails was measured volumetrically before injection and 1, 2, and 3 days afterwards. The clinical responses of the mice to PAO were observed up to 30 days. The development of inflammation corresponded well with the quantity of enzyme used. The data obtained indicated the smallest dose (0.005 mg) of PAO induced oedemization of the tail (P
Why do you need a reservation system?      Save time & money - Smart Internet Solutions