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The induction of inflammation in mouse tails with Aspergillus oryzae protease and the inhibitory effects of synthetic and natural sub stances in vitro

Author(s): Šutiak V. | Korenek M. | Sutiakova Irena | Korenekova Beata | Sobekova Anna | Vaško L. | Neuschl J.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 52;
Issue: 5-6;
Start page: 345;
Date: 2002;
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Keywords: inflammation | inhibitors | measurements | mice | oedema | protease

Four groups of male mice were injected with doses from 0.005 to 1.0 mg of protease ex Aspergillus oryzae (PAO) in 20.0 (l of a 0.9 % physiological saline solution (PSS) per mouse s.c. into their tails. The control mice received 20.0 (l of 0.9% PSS only. The inflammation of the tails was measured volumetrically before injection and 1, 2, and 3 days afterwards. The clinical responses of the mice to PAO were observed up to 30 days. The development of inflammation corresponded well with the quantity of enzyme used. The data obtained indicated the smallest dose (0.005 mg) of PAO induced oedemization of the tail (P
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