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Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients

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Author(s): Mahmood Soveid | Kazem Hosseini Asl | Gholamhossein Ranjbar Omrani

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 1;
Start page: 48;
Date: 2012;
Original page

Keywords: Autoimmune Thyroid Disease | Cag A | Graves΄ Disease | Helicobacter pylori

ABSTRACT
Background: Infectious agents have been suspected as a triggering factor for developmentof autoimmune thyroid disease (ATD). Some reports from Western countries havesuggested association between Helicobacter pylori (HP) infection and ATD. Objective:To investigate the association of ATD with Cag A seropositivity in a population withhigh rate and early age of onset of HP infection. Methods: IgG anti HP and anti Cag Aantibodies were measured in 88 patients with ATD and compared with results of 112healthy individuals. Results: The rate of infection with HP was not significantly differentin patient and control groups, but there was significant association between ATDand infection with Cag A strains (p
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