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Influence of bushenhuoxue on primary visual cortex' BDNF damage in rat model of chronic elevated intraocular pressure

Author(s): Xiang Li | Hong-Jian Guo | Xiao-Xia Wen | Zhao Xie | Xue-Jun Xie | Xue-Jing Lu | Yi Wang | Jing Zhang

Journal: Guoji Yanke Zazhi
ISSN 1672-5123

Volume: 13;
Issue: 4;
Start page: 647;
Date: 2013;
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Keywords: glaucoma | rat model of chronic elevated intraocular pressure | TCM of bushenhuoxue | primary visual cortex | nissl bodies | ultrastructure of neuron cell

AIM: To observe the effect of traditional Chinese medicine(TCM)of bushenhuoxue on primary visual cortex(PVC)brain-derived neurotrophic factor(BDNF)in rat model of chronic elevated intraocular pressure(EIOP), and explore the mechanism of it initially. METHODS: The rat model of chronic EIOP was established by unilaterally cauterizing 3 episcleral veins, then 30 rats were divided into 3 groups randomly: control group, model group, and treatment group. After given drugs or normal saline for 8 weeks, the rats were put to death. The effect of intraocular pressure(IOP), expression of BDNF and ultrastructure of neuron cell in the PVC was observed. RESULTS: Unilaterally cauterizing episcleral veins increased IOP of the rat model obviously, there was significant difference compared with pre-operation(P
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