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The influence of caffeine on the biomechanical properties of bone tissue during pregnancy in a population of rats

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Author(s): Grazyna Olchowik | Emilia Chadaj-Polberg | Marek Tomaszewski | Mateusz Polberg | Monika Tomaszewska

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 49;
Issue: 3;
Start page: 504;
Date: 2011;
Original page

Keywords: caffeine | pregnancy | bone tissue | static mechanical properties

ABSTRACT
The influence of pregnancy on bone tissue metabolism is not completely understood. Caffeine alsohas a potentially negative influence on bones. The aim of this study was the evaluation of changes in the bones ofpregnant rats under the influence of caffeine. The experiment was carried out on Wistar rats. The evaluation ofrats’ bone tissue quality was performed based on bone density measurements and resistance examinations. Itanalyzed the impact of caffeine on the degree of bone tissue mineralization and the composition of the bones.The mean value of pelvises ‘wet’ and ‘dry’ densities in a group of pregnant rats with caffeine intake was lowercompared to the control group. The deformation in maximal load point of the femur shaft in the experimentalgroup was significantly higher than in the control group. In the experimental group, the percentage of water inthe bones was significantly higher, while the content of inorganic phase was significantly lower compared to thecontrol group. The changes of biomechanical parameters in the group of pregnant rats with caffeine intakeindicate its negative influence on the bone. Our results show higher plasticization of the bone shafts of theanimals under the influence of caffeine. Higher deformation of bone shafts may have an effect on the statics ofthe skeleton. The administration of caffeine significantly affected the quantitative composition of the bone.(Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 504–511)

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