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The influence of dental care associated with laser therapy on oral mucositis during allogeneic hematopoietic cell transplant: retrospective study

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Author(s): Fernanda de Paula Eduardo | Letícia Mello Bezinelli | Mariane Couto Estácio Orsi | Morgani Rodrigues | Martha Simões Ribeiro | Nelson Hamerschlak | Luciana Correa

Journal: Einstein
ISSN 1679-4508

Volume: 9;
Issue: 2;
Start page: 201;
Date: 2011;
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Keywords: Oral health | Bone marrow transplantation | Stomatitis | Graft vs host disease

ABSTRACT
Objective: To verify decrease in frequency and severity of oralmucositis in patients submitted to dental care and laser therapyduring allogeneic hematopoietic cell transplant. Methods: Medicalrecords of patients submitted or not to dental care associatedwith laser therapy during allogeneic transplant were reviewed.The following data were collected: sex, age, underlying disease,myeloablative conditioning regimens, prophylaxis for graftversus host disease, extension and severity of oral mucositis,pain in the oral cavity and when swallowing, diarrhea, need ofperipheral parenteral nutrition and presence of acute graft versushost disease. Results: Significant reduction in extension andseverity of oral mucositis, as well as in frequency of oral cavitypain, was observed in patients with dental care/laser therapy(p < 0.01). There were no statistically significant differencesregarding frequency of diarrhea, pain when swallowing, and needof parenteral nutrition among the groups. Significant associationwas found between acute graft versus host disease and painwhen swallowing (p < 0.01). Acute graft versus host diseasewas not associated with oral mucositis severity, oral cavity pain,and diarrhea. Conclusion: Dental care associated with lasertherapy reduces the extension and severity of oral mucositis inpatients with allogeneic hematopoietic transplant. Further studiesare necessary to clarify the isolate efficacy of laser therapy inthese conditions, mainly regarding the influence of reduced oralmucositis on the graft versus host disease.
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