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Influence of Spray-Dryer Operating Variables on the Quality of Vernonanthura ferruginea (Less.) H. Rob. Extracts With Antiulcer Potential

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Author(s): Ezequiane Machado Silva Oliveira1, Renê Oliveira Couto1, Mariana Viana Pinto1, José Luís Rodrigues Martins2,

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3251;
Date: 2011;
Original page

Keywords: Powder technology | spray drying | physicochemical properties | phytopharmaceuticals | lupeol | colloidal silicon dioxide.

ABSTRACT
The influence of the proportion of drying adjuvant (colloidal silicon dioxide), the drying air inlet temperature, and the extract feed rate on some properties ofspray-dried extracts of V. ferruginea has been investigated in this work. A 23 full factorial design was followed and the effects of operating variables were evaluatedby ANOVA/RSM. It was observed that none of the factors studied had significant effects on the process yield, moisture content, and water activity. However, theyexerted significant effects on the lupeol content, a compound used as technological marker. Using a high colloidal silicon dioxide proportion (20%), a low dryingair inlet (80ºC) temperature and a low extract feed rate (4 mL.min -1), the lupeol content and process yield were higher, 2.47% (w/w) and 30.82% (w/w), respectively.This condition also allowed obtainment of powders with low moisture content and water activity, proving to be the best among the tested conditions to obtainlupeol standardized dried extracts of V. ferruginea. Moreover, the dried extract obtained showed lupeol content 14.5 times greater than the powder of leaves andafforded gastroprotection against indomethacin-induced gastric lesions in mice, thus favoring its use as an intermediate phytopharmaceutical product.
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