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Inhaled nitric oxide: clinical effects and influence on the profile of inflammatory markers in patients with idiopathic pulmonary hypertension

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Author(s): T.V. Martynyuk | S.N. Nakonechnikov | V.P. Masenko, I.E. Chazova | I.E. Chazova

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 8;
Issue: 4;
Start page: 500;
Date: 2012;
Original page

Keywords: idiopathic pulmonary hypertension | nitric oxide | cytokines | inflammation

ABSTRACT
Aim.To study the effect of treatment with inhaled nitric oxide (iNO) on the clinical status of patients with idiopathic pulmonary hypertension (IPH), and the profile of proinflammatory cytokines in peripheral blood.Material and methods.Patients with IPH (n=48) were included into the study. Evaluation of the IPH functional class (FC), the 6-minute walk test (6MWT) with the assessment of the Borg index, echocardiography, laboratory tests [blood count, evaluation of high-sensitivity C-reactive protein (hsCRP), interleukins (IL), interferon-γ (INFγ), tumor necrosis factor α (TNFα), macrophage inflammatory protein α (MIP1 α), soluble adhesion molecules (sICAM-1, sVCAM-1) in peripheral blood] were performed at baseline and on day 21 of iNO therapy course. The iNO course 40 ppm during 5 hours a day for 21 days was carried out additionally to the standard IPH therapy under the toxicity control by the PrinterNOx (England).Results.Increase in exercise tolerance, improvement of IPH FC (from 3.35±0.52 to 2.71±0.56; p=0.008), reduction in systolic pulmonary artery pressure (SPAP) by Doppler echocardiography (from 96.23±23.65 to 82.36±20.92 mmHg; p
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