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Inhibition of Cancer Cell Proliferation in vitro and Tumor Growth in vivo by Hydrophis spiralis Sea Snake Venom

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Author(s): R. Karthikeyan | S. Karthigayan | M. Sri Balasubashini | S. Vijayalakshmi | S.T. Somasundaram | T. Balasubramanian

Journal: International Journal of Cancer Research
ISSN 1811-9727

Volume: 3;
Issue: 4;
Start page: 186;
Date: 2007;
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Keywords: Cell line | Ehrlich`s ascites carcinoma | antitumor | sea snake venom | Hydrophis spiralis

ABSTRACT
Hydrophis spiralis) was evaluated against Ehrlichs Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 g mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.]]>
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