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Inhibition efficiency of urine towards stone forming minerals.

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Author(s): Dr. Seema Jawalekar, | Dr. V.T.Survey, | Dr. Anil K. Bhutey

Journal: International Journal of Pharma Sciences and Research
ISSN 0975-9492

Volume: 1;
Issue: 1;
Start page: 23;
Date: 2010;
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Keywords: kidney stone | promoters | inhibitors | hypocitraturia | hyperoxaluria | Crystallization.

ABSTRACT
Urine specimens were collected from 100 normal individuals and 100 kidney stone patients and analysed spectrophotometrically for common stone promoters like oxalate, calcium, uric acid and phosphate and stone inhibitors like citrate and magnesium. Inhibition efficiency by these inhibitors exiting in urine samples towards the mineralisation of urinary stone forming minerals like calcium oxalate ,phosphate or carbonate has been studied in an experimental model. The results were presented as mean ± SD, student’s t test was used for statistical analysis. Hypocitraturia and hyperoxaluria were the common bnormalities in the stone formers. Kidney stone patients had significantly higher urinary oxalate, calcium and uric acid and lower phosphate than normal individuals. The efficiency is markedly higher for phosphate, carbonate and urates by healthy urine samples.For the stubborn mineral oxalate has low inhibition efficiency. The urine of stone formers show very little inhibition. This implies that inhibition of crystal growth is proportional to the concentration of inhibitory factor present.
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