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Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants

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Author(s): Zahra Amirghofran | Saeed Malek-Hosseini | Hossein Golmoghaddam | Fathollah Kalantar | Mehdi Shabani

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 3;
Start page: 159;
Date: 2011;
Original page

Keywords: Cytokines | Medicinal Plants | Nitric Oxide

ABSTRACT
Background: A number of medicinal plants have been used to treat variousimmunological diseases. Nitric oxide (NO) has an important regulatory role in thevarious types of inflammatory processes. Objective: To investigate the NO modulatoryactivity of the extracts of several medicinal plants native to Iran includingDracocephalum kotschyi, Linum persicum, Dionysia termeana, Salvia mirzayanii,Ferulago angulata and Euphorbia cheiradenia. Methods: The methanolic extracts ofthe plants were prepared and examined for their effects on the NO production bylipopolysaccharide-stimulated mouse macrophages. The level of TNF-α and IL-1β proinflammatorycytokines in the macrophage culture were detected using enzyme-linkedimmunosorbent assay. Results: All the extracts at concentration of 50 μg/mldemonstrated a significant decrease in NO production (p
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