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INOTROPIC AND CARDIOPROTECTIVE EFFECT OF TERMINALIA PANICULATA ROTH BARK EXTRACT IN DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS

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Author(s): Davey M.S. | Atlee C.W.

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 3;
Start page: 869;
Date: 2011;
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Keywords: Cardioprotective | Terminalia paniculata | Myocardial infarction | Doxorubicin | Vitamin E | Cardiac biomarkers | Antioxidants.

ABSTRACT
Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with Terminalia paniculata bark extract were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of ethanolic extract of Terminalia paniculata (EETP) bark against doxorubicin induced cardiotoxicity in rats and to compare with vitamin E, a known cardioprotective antioxidant. Extract was given orally to rats (200mg/kg/day and 400mg/kg/day for 28 consecutive days), Vitamin E was given orally (100mg/kg/day for 28 consecutive days) and DOX (15 mg/kg; i.p.) was administered on the 29th day to induced cardiotoxicity. EETP protected against DOX-induced increased in heart weight. It significantly inhibited DOX-provoked elevation in serum lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT), creatine kinase-MB (CK-MB) as well as troponin I level. The reductions in cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px) were also significantly mitigated. Elevation of cardiac lipid peroxidation (LPO) activity in response to DOX treatment was significantly hampered. Pretreatment with extract significantly guarded against DOX-induced decreased in cardiac ATPase activity like Ca+2 ATPase, Na+–K+ ATPase and Mg+2 ATPase. EETP alleviated histopathological changes in rats heart treated with DOX. Finally we concluded that Terminalia paniculata bark extract exerts equipotent cardioprotective and inotropic activity in the experimental model of doxorubicin induced myocardial infarction in rats as compared to vitamin E, a known cardioprotective antioxidant.
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