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Insulin-like growth factor-1 receptor expression in oral squamous cell carcinoma

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Author(s): Boby K. Joseph | Devipriyaa B. Sundaram

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 4;
Start page: 354;
Date: 2011;
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Keywords: Growth factors | insulin-like growth factor receptor | epithelial dysplasia | Oral squamous cell carcinoma | immunohistochemistry

ABSTRACT
Objectives: The Insulin-like growth factor-I receptor (IGF-1R) plays critical roles in cancer development, proliferation, motility and survival. IGF-1R over expression is frequently found in various tumours and is often associated with an aggressive phenotype. Hence, the aim of the present study was to examine the expression of IGF-1R in normal oral mucosa, fibroepithelial polyps, dysplastic oral mucosa and well-differentiated squamous cell carcinomas.Materials and methods: A 3-layered streptavidin peroxidase immunohistochemical method was used to detect the expression of IGF-1R in normal oral mucosa, fibroepithelial polyps, dysplastic oral mucosa and well-differentiated squamous cell carcinomas.Results: All squamous cell carcinomas (15 out of 15 patients) showed intense immunoreactivity for IGF-1R. Moderate immunoreactivity was seen in dysplastic oral lesions (12 out of 12 lesions) with positive staining in the prickle cell layer. The staining distribution in the benign lesions (14 out of 14 lesions) was weaker and similar to that seen in normal oral mucosa (10 out of 10 samples) when compared to squamous cell carcinomas and dysplastic lesions.Conclusions: Our results demonstrate increased IGF-1 receptor expression in oral squamous cell carcinomas which suggests that IGF-1 may have an important role in the development of oral cancer. J Clin Exp Invest 2011; 2 (4): 354-361
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