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An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research

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Author(s): Gracie Sara | Pennell Craig | Ekman-Ordeberg Gunvor | Lye Stephen | McManaman James | Williams Scott | Palmer Lyle | Kelley Maureen | Menon Ram | Gravett Michael

Journal: BMC Pregnancy and Childbirth
ISSN 1471-2393

Volume: 11;
Issue: 1;
Start page: 71;
Date: 2011;
Original page

ABSTRACT
Abstract Preterm birth is the leading cause of neonatal mortality and perinatal morbidity. The etiology of preterm is multi-factorial and still unclear. As evidence increases for a genetic contribution to PTB, so does the need to explore genomics, transcriptomics, proteomics and metabolomics in its study. This review suggests research guidelines for the conduct of high throughput systems biology investigations into preterm birth with the expectation that this will facilitate the sharing of samples and data internationally through consortia, generating the power needed to study preterm birth using integrated "-omics" technologies. The issues to be addressed include: (1) integrated "-omics" approaches, (2) phenotyping, (3) sample collection, (4) data management-integrative databases, (5) international consortia and (6) translational feasibility. This manuscript is the product of discussions initiated by the "-Omics" Working Group at the Preterm Birth International Collaborative Meeting held at the World Health Organization, Geneva, Switzerland in April 2009.
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