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Interaction of fluoroquinolones with commonly used NSAIDs and CNS depressants

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Author(s): Suneel. I. Majagi*1, L. S. Chauhan2, P. A. Patil1.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3146;
Date: 2011;
Original page

Keywords: Fluroquinolones | NSAIDs | Diazepam | Pentobarbitone | Magnesium sulphate.

ABSTRACT
To investigate the influence of commonly used fluroquinolones viz., ciprofloxacin and pefloxacin on acute as well as sub-acute inflammation and theirpossible interactions with some commonly used NSAIDs and CNS depressants. Materials and methods: Single therapeutic equivalent dose of ciprofloxacin,pefloxacin, aspirin, diclofenac and ibuprofen were administered to see their effect on carrageenan induced inflammation by measuring paw volume. For interactionstudies both the flouroquinolones were individually coadministered with each of the NSAIDs. For sub-acute inflammation studies aspirin, ciprofloxacin, pefloxacin,ciprofloxacin with diclofenac and ciprofloxacin with ibuprofen were administered every 24 hours for 10 days. Granulation tissue dry weight and histopathologywere assessed. For CNS interactions studies single dose of ciprofloxacin and pefloxacin alone and in combination with aspirin were administered to elicit therapeuticeffect on sleep time induced by diazepam, pentobarbitone and magnesium sulphate. Results: Ciprofloxacin and pefloxacin showed significant anti-inflammatoryactivity only in sub-acute model. Ciprofloxacin and pefloxacin did not show significant interaction with NSAIDs with respect the anti-inflammatory activity.Ciprofloxacin with aspirin significantly reduced sleep induced by diazepam, pentobarbitone and magnesium sulphate while ciprofloxacin alone and pefloxacin withaspirin significantly reduced sleep induced by magnesium sulphate. Conclusion: These findings indicate that fluoroquinolones like ciprofloxacin and pefloxacindo not significantly alter the anti-inflammatory activity of NSAIDs like aspirin, diclofenac and ibuprofen. Ciprofloxacin when co-administered with NSAIDs likeaspirin, as it is often done in the clinical practice, can interfere with the hypnotic activity of diazepam.
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