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The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?

Author(s): Maurizio Brigotti

Journal: Toxins
ISSN 2072-6651

Volume: 4;
Issue: 3;
Start page: 157;
Date: 2012;
Original page

Keywords: Shiga toxins | ricin | ribosome-inactivating proteins | polymorphonuclear leukocytes | hemolytic uremic syndrome

Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that recognizes molecular patterns common to foreign molecules through specific receptors expressed on the surface of the main actors of innate immunity, namely monocytes and neutrophils. The interactions between these toxins and neutrophils have been widely described and have stimulated intense debate. This paper is aimed at reviewing the topic, focusing particularly on implications for the pathogenesis and diagnosis of hemolytic uremic syndrome.
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