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Intra-Articular Hyaluronic Acid (Synject) In The Management Of Osteoarthritis Of The Knee In Nigeria - An Initial Report

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Author(s): Alonge TO*, Ogunlade SO , Omololu AB, Ifesanya A, Nottidge TE.

Journal: Journal of Orthopaedics
ISSN 0972-978X

Volume: 5;
Issue: 1;
Date: 2008;
Original page

Keywords: Osteoarthritis | Synovial joint | Hyaluronic acid | Pain Relief

ABSTRACT
Background: Osteoarthritis is the commonest disorder of the synovial joints. It is potentially a very disabling chronic disease often associated with pain and joint stiffness among other symptoms. Pain is the main reason for the patient seeking medical attention, therefore most forms of therapy are aimed at achieving adequate pain relief. The use of oral medications can be problematic with issues such as poor patient compliance and various adverse drug reactions have been credited to these drugs including the coxib group. In the orthopaedic community in West Africa, there is now a move towards the use of intra-articular injections (particularly hyaluronic acid as sodium hyaluronate) as the primary treatment option in knee osteoarthritis. Aim: To evaluate the short-term pain relief in patients with knee osteoarthritis following the injection of 1% hyaluronic acid. Study Design and location: Prospective study carried out at the University College Hospital, Ibadan, South-Western Nigeria, West Africa. Method: 20 consecutive patients with clinical and radiological diagnosis of knee osteoarthritis seen at the Orthopaedic outpatients clinic at the University College Hospital, Ibadan, were entered into the study and were scheduled to receive a total of three injections into the affected knee on a weekly basis. The pain intensity was evaluated using the Visual Analogue Scale (VAS) prior to each injection. 11 knees in 8 patients completed this study with the prescribed number of intra-articular injections. An intention to treat analysis was used. Results: There was significant reduction in knee pain following each injection (particularly between week 1 and week 3 injections) and this was sustained over a short period of 12 weeks follow-up. Conclusion: In patients with knee OA who are also poor responders or intolerant to non-steroidal anti-inflammatory drugs, intra-articular Synject (1% hyaluronic acid) offers an alternative but effective therapy for the relief of pain.
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