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Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride

Author(s): Sami El-Sayrafi | Saleh Rayyan

Journal: Molecules
ISSN 1420-3049

Volume: 6;
Issue: 3;
Start page: 279;
Date: 2001;
Original page

Keywords: Pyrophosphoryl chloride | Phosphorus oxychloride | Cyclodehydration | Cyclic ketones | Anthraquinones

Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthrones and anthraquinones respectively.
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