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Intranasal sufentanil for postoperative pain control in lower abdominal pediatric surgery

Author(s): Farhad Heshmati | Heidar Noroozinia | Rahman Abbasivash | Helen Gharaee

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 5;
Issue: 2;
Start page: 131;
Date: 2006;
Original page

Keywords: Analgesia | Intranasal | Sufentanil | Pediatric | Postoperative pain

Introduction: The most important role in postoperative pain management is still played by opioids administered through various modes. In the last few years, there had been an intensive search for alternative mode of opioids administration in pain management. The intranasal mode of opioids administration seems to be attractive alternative. Methods: Sixty boys (aged 0.5-6 yr); ASA physical status I, II were included in this prospective randomized controlled study. Five minutes before awake extubation, patients were allocated to receive intranasal sufentanil (0.7 µg/kg) or normal saline, using a double-blinded study design.Results: Satisfactory analgesia was achieved with sufentanil (p = 0.001) and it was effective during time, after 10 minutes with the least pain scores. Pain scores in 15, 20 and 25 minutes were similar in sufentanil group. None of patients had bradycardia, hypotension or SpO2
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