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Intrauterine Growth Restriction in Term Women with Histologic Chorioamnionitis

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Author(s): R. Hemalatha | B.A. Ramalakshmi | S.S.Y.H. Quadri | N. Balakrishna | V.V. Annapurna | B. Sesikeran

Journal: Research Journal of Obstetrics and Gynecology
ISSN 1994-7925

Volume: 1;
Issue: 1;
Start page: 18;
Date: 2008;
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Keywords: Histologic chorioamnionitis | inflammatory response | intrauterine growth restriction

ABSTRACT
The present research aims at studying the association of histologic chorioamnionitis (HCA) with intrauterine growth restriction (IUGR). Women at labor were recruited for this study from Niloufer Hospital, Hyderabad, India. These women were screened for HCA and Bacterial Vaginosis (BV). IL8 and TNF α concentration were measured in the Chorioamnion membranes collected from all these women. New born anthropometry were collected and using Lubchenco et al. standard, percentile weight for gestation age was assessed, sexes combined. Nearly twenty nine percent of women had histologic chorioamnionitis and these women had higher proportion of babies with less than 10th percentile birth weight, crown heel length and head circumference. Compared to women with asymmetrical growth retarded babies, women with symmetrically growth-retarded babies were associated with higher proportion of histologic chorioamnionitis, however bacterial vaginosis was not associated with either HCA or birth outcome. Women with histologic chorioamnionitis had significantly higher concentration of IL8 while women with BV had no association with cytokine secretion. The present study shows that intrauterine inflammation; a strong predictor of intrauterine infection is associated with fetal growth, while bacterial vaginosis-a lower genital tract infection is not associated. However, the association is not robust, which could be due to bias towards selecting a population that belongs to low socio economic status and thus high prevalence of chronic low-grade infection resulting in higher prevalence of inflammation in most of the women in the study. More controlled studies are required to delineate the role of infection/inflammation on intrauterine growth.
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