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INTRAUTERINE HYPOXIA OF FETUS - INFLUENCE OF ULTRA-LOW DOSES OF ANTIOXIDANT (EXPERIMENTAL RESEARCH)

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Author(s): ZARINA KHAYBULLINA

Journal: Medical and Health Science Journal
ISSN 1804-1884

Volume: 8;
Issue: 4;
Start page: 41;
Date: 2011;
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Keywords: Hypoxia | reactive oxygen species | antioxidant | Fenozan.

ABSTRACT
Oxygensensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic lowoxygen condition, but intensive production of reactive oxygen species (ROS) can cause cell destruction. Previous studies revealed that the hypoxia induces oxidative stress and neurodegeneration, which is associated with memory, behavioral, and learningeducation impairment in children. In the view of the abovestated concept, the study of influence of ultra low doses of antioxidant on ROS generation and activity of enzymes of antioxidant protection in a brain and blood at intrauterine hypoxia of a fetus appears appealing. The effect of Fenozan in ultra low doses was evaluated in the rats underwent intrauterine hypoxia. Research was made on white rats, 66 pregnant females and 279 infant rats (021 days). It was established, that chronic prenatal hypoxia is accompanied by accumulation of malondialdehyde in brain tissue, blood and subcellular fractions of a liver, with the subsequent spontaneous normalization of its maintenance by 21st day in a brain and blood.Fenozan injection in ultra low doses leads to appreciable decrease in MDA level and increase of the ROSscavenging enzymes at first in a brain and peripheral blood, and then in microsomal and mitochondrial fractions of the liver, that is the precondition for normalization of pathological process in earlier terms. Significance of this data argues that ultra low doses of Fenozan can be less invasive and effective in the treatment of chronic intrauterine hypoxia and suggest the directions for further research.
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