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Intrauterine transplantation of autologous bone marrow derived mesenchymal stem cells followed by conception in a patient of severe intrauterine adhesions

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Author(s): Yong Zhao | Aiming Wang | Xiaorong Tang | Min Li | Ling Yan | Wei Shang | Meizhu Gao

Journal: Open Journal of Obstetrics and Gynecology
ISSN 2160-8792

Volume: 03;
Issue: 03;
Start page: 377;
Date: 2013;
Original page

Keywords: Intrauterine Adhesions | Asherman’s Syndrome | Bone Marrow Derived Mesenchymal Stem Cells | Pregnancy

ABSTRACT
On a woman with severe intrauterine adhesions, hysteroscopy followed by cyclical hormone replacement therapy was tried for 5 months, for development of the endometrium. When this failed, autologous stem cells were tried as an alternative therapy. Adult autologous bone marrow mesenchymal stem cells isolated from patient’s own bone marrow and were cultured and placed in the endometrial cavity under ultrasound guidance after curettage. Patient was then given cyclical hormonal therapy. Endometrium was assessed intermittently using ultrasound. Three months later, endometrium partly recovered with improved ultrasonic echo. This resulted in spontaneous pregnancy followed by confirmation of gestational sac, yolk sac, and primitive heart tube pulse on ultrasound. Autologous bone marrow derived mesenchymal stem cells could regenerate injured endometrium not responding to conventional treatment and can be used as an alternative in females with severe Asherman’s syndrome. 
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