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INVERSE CORELLATION OF CRP AND SERUM IRON IN PATIENTS WITH SIMPLE COMMUNITY- ACQUIRED PNEUMONIA (CAP)

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Author(s): Desa Nastasijevic Borovac | Tatjana Radjenovic Petkovic | Tatjana Pejcic | Milan Rancic | Vidosava B Djordjevic

Journal: Acta Facultatis Medicae Naissensis
ISSN 0351-6083

Volume: 24;
Issue: 3;
Start page: 107;
Date: 2007;
Original page

Keywords: inflammation | hypoferremia | pneumonia

ABSTRACT
The inflammatory response associated with infection, synthesis acute phase proteins (APPs), shifts iron from the circulation into storage in order to protect the organism. The prospective study included 47 patients (15 female, 32 male) with simple Community-acquired pneumonia (CAP) (mean age 62.4 ± 15.4 years). The patients did not use the supplementary iron therapy. We measured the white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), total iron binding capacity (TIBC), serum iron and calculated transferrin. Blood samples were analyzed on the first day (group I) and after 6-8 days of hospitalization (group II). The aim of the investigation was to describe segmental changes and correlation of APPs and serum iron during the diagnostic work-up and antibiotic treatment. CRP (166.95 ± 79.04 mg/L) showed decrease in group II (28.68±26.59 mg/L) (p

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